• interface to specialized h/w (e.g., gene sequencers, mass spectrometers, digital microscopes, etc.)
• processing large amounts of data (many files)
• processing large amounts of data (test sets/base sets can be huge)
• often coarse grained parallelism
• cultural gap between CS and Bio folks -- different languages & cultures
• computational complexity -- e.g., molecular modeling, finding binding sites, drug discovery
• statistics -- data mining weak signals from large sets of interdependent data
• statistics and experimental design, e.g., the drug discovery, clinical trial & approval pipeline
• interrelational complexity, such as biochemical cell pathways (who does what to whom, and in what sequence; where to intervene)
• user interface for navigating/visualizing/utilizing the enormous amount of data

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